Rudolph Tanzi Biography

Rudolph E. Tanzi Ph.D. Director Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative Diseases Department of Neurology Massachusetts General Hospital Joseph P. and Rose F. Kennedy Professor of Neurology (Neuroscience Program affiliate) Harvard Medical School
Dr. Rudolph Tanzi is a Professor of Neurology and holder of the Joseph P. and Rose F. Kennedy Endowed Chair in Neurology at Harvard Medical School. At Massachusetts General Hospital (MGH) Dr. Tanzi serves as the Director of the Genetics and Aging Research Unit which consists of seven laboratories investigating the genetic causes of Alzheimer's disease. Dr. Tanzi has been investigating the molecular and genetic basis of neurological disease since 1980 when he participated in the pioneering study that led to the location of the Huntington's disease gene the first disease gene to be found by genetic linkage analysis. Since 1982 Dr. Tanzi has investigated the genetic causes of Alzheimer's disease (AD). He co-discovered all three genes that cause early-onset familial AD including the first familial AD gene known as the amyloid -protein (A4) precursor (APP) and the presenilin genes. In 1993 Dr. Tanzi discovered the gene responsible for the neurological disorder known as Wilson's disease and over the past 25 years he has collaborated on studies identifying several other disease genes including those causing amyotrophic lateral sclerosis and autism. Dr. Tanzi currently spearheads the Alzheimer's Genome Project which recently identified four new AD gene candidates. This achievement was named one of the Top Ten Medical Breakthroughs of 2008 by Time magazine. In 1994 Dr. Tanzi discovered that the metals zinc and copper are necessary for the formation of neurotoxic assemblies of the A peptide the main component of -amyloid deposits in brains of AD patients. Based on this discovery Dr. Tanzi developed the Metal hypothesis of Alzheimer's disease which has led to successful clinical trials for treating and preventing AD by targeting Ametal interactions. These trials were carried out by Prana Biotechnology LTD for which Dr. Tanzi served as a co-founder.

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