Pamela Ronald Biography

Pamela Ronald is Professor in the Department of Plant Pathology and the Genome Center at the University of California Davis. She serves as Director of Grass Genetics at the Joint Bioenergy Institute. Her laboratory has genetically engineered rice for resistance to diseases and flooding which are serious problems of rice crops in Asia and Africa. In 1995 the Ronald Laboratory isolated and characterized the XA21 pattern recognition receptor (Song et al. Science 1995: Lee et al. Science 2009). Subsequent discoveries in flies humans mice and Arabidopsis revealed that animals and other plant species also carry membrane-anchored receptors with striking structural similarities to XA21 and that these receptors also play key roles recognition of microbial signatures and host defense. The Ronald laboratory in collaboration with David Mackill isolated the Submergence tolerance 1 (Sub1) QTL through a map-based cloning approach (Xu et al. 2006). This work revealed a complex locus of three genes carrying three genes that encode putative transcriptional regulators of the AP2 class. Through transgenic analysis the Ronald laboratory demonstrated that the overexpression of Sub1a is sufficient to confer submergence tolerance to intolerant varieties. Mackill's group at the International Rice Research Institute introduced the Sub1QTL into agronomically important varieties using a marker assisted backcross selection strategy.

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