Gero Miesenboeck Biography

Gero Miesenboeck is pioneering the field of optogenetics: genetically modifying nerve cells to respond to light. By flashing light at a modified neuron in a living nervous system Miesenboeck and his collaborators can mimic a brain impulse -- and then study what happens next. Optogenetics will allow ever more precise experiments on living brains allowing us to gather better evidence on how electrical impulses on tissue translate into actual behavior and thoughts.
In one experiment done at Yale he and his team engineered fruit flies to be light-sensitive in the neural area responsible for escape response. Then the flies were beheaded; fruit flies can live for a day without their heads but they don't move. When the modified cells were flashed with light though the headless flies flew. Miesenboeck had successfully simulated an order from a brain that wasn't even there anymore.
Miesenboeck's current research at Oxford's growing department of neurobiology focuses on the nerve cell networks that underpin what animals perceive remember and do. In one recent experiment he used optogenetics to implant an unpleasant memory in a fruit fly causing it to remember to avoid a certain odor as it traveled around. He and his team were able in fact to find the fly's specific 12-neuron brain circuit that govern memory formation.

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